Cart
sales@molnova.com
Home - Products - Membrane Transporter/Ion Channel - GlyT - PF-03463275 B

PF-03463275 B

CAS No. 1173239-39-8

PF-03463275 B( —— )

Catalog No. M35572 CAS No. 1173239-39-8

PF-03463275 is an orally active and selective reversible inhibitor of competitive glycine transporter protein-1 (GlyT1) with a Ki of 11.6 nM.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
Size Price / USD Stock Quantity
2MG 78 Get Quote
5MG 116 Get Quote
10MG 187 Get Quote
25MG 306 Get Quote
500MG Get Quote Get Quote
1G Get Quote Get Quote
Get Quotation Bulk Inquiry Add to Cart

Biological Information

  • Product Name
    PF-03463275 B
  • Note
    Research use only, not for human use.
  • Brief Description
    PF-03463275 is an orally active and selective reversible inhibitor of competitive glycine transporter protein-1 (GlyT1) with a Ki of 11.6 nM.
  • Description
    PF-03463275 is a centrally penetrant, orally available, selective, and competitive GlyT1 (glycine transporter-1) reversible inhibitor, with a Ki of 11.6 nM. PF-03463275 has the potential for Schizophrenia research.
  • In Vitro
    ——
  • In Vivo
    PF-03463275 (1-10 mg/kg; s.c.) attenuates oscillatory potentials (OPs).Animal Model:Male Sprague-Dawley rats Dosage:1, 3 and 10 mg/kg Administration:S.c.Result:A dose-dependent reduction in the amplitude of oscillatory potentials (OPs) elicited from the dark-adapted rats.
  • Synonyms
    ——
  • Pathway
    Membrane Transporter/Ion Channel
  • Target
    GlyT
  • Recptor
    GlyT
  • Research Area
    ——
  • Indication
    ——

Chemical Information

  • CAS Number
    1173239-39-8
  • Formula Weight
    376.86
  • Molecular Formula
    C19H22ClFN4O
  • Purity
    >98% (HPLC)
  • Solubility
    In Vitro:?DMSO : 33.33 mg/mL (88.44 mM; Ultrasonic )
  • SMILES
    [H][C@@]12CN(C)C[C@]1([H])[C@H]2CN(Cc1ccc(F)c(Cl)c1)C(=O)c1cn(C)cn1
  • Chemical Name
    ——

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1. Lowe JA 3rd, et al. The discovery of a structurally novel class of inhibitors of the type 1 glycine transporter [published correction appears in Bioorg Med Chem Lett. 2009 Aug 15;19(16):4885. Bronk, Brian S [added]; Schaeffer, Eric [added]]. Bioorg Med Ch?
Calculator

Molecular Weight Calculator

Dilution Calculator

Molarity Calculator

molnova catalog
related products

  • Iclepertin

    Iclepertin (BI-425809) is an orally active and selective inhibitor of glycine transporter protein 1 (GlyT1).Iclepertin is used for the treatment of central nervous system disorders such as Alzheimer;s disease.

  • ALX-5407 hydrochlori...

    ALX-5407 is a potent, selective, orally active inhibitor of GlyT1 glycine transporter with IC50 of 3 nM.

  • Bitopertin R enantio...

    A potent and selective GlyT1 inhibitor with EC50 of 54 nM.

Sign In Join Free